I joined the Princess Máxima Center as a basic researcher and pediatrician in training in June 2018. My primary research interest lies in understanding the molecular biology of pediatric soft tissue sarcomas (STS) and to use that knowledge to develop new treatment options for patients suffering from these tumors. To this end, I study establishment procedures for novel preclinical models of pediatrist STS (i.e., tumor organoid models) as well as bulk and single-cell genomics of these tumors. I am furthermore member of the molecular tumor board of the Dutch iTHER as well as the German INFORM pediatric precision medicine trial.
My hobbies include sports (running, bootcamp) and gaming (board games, tabletop role-playing games, video games). I am the proud father of a boy and a girl.
Post Doc (bioinformatician)
I am a Bioinformatician involved in curation, management and analysis of pre-clinical and clinical, multi-omics data from soft tissue sarcoma (rhabdo- and non-rhabdo-) patients. In the pre-clinical setting, I focus on the analysis of patient-derived tumoroids and how they resemble the tumor of origin to gain insights into the underlying biology and to investigate potentially novel therapeutic avenues. Furthermore, I work towards the generation of useful tools such as interactive web-based apps and static reports to better disseminate these results to internal and external partners. One such tool is the webpage https://rmsdata.rms-biobank.eu, which contains multi-omics data from patient-derived rhabdomyosarcoma tumoroids that were established at the Máxima. There, users can check gene expression, structural and single nucleotide variants, as well as drug screening profiles, from a diverse panel of 19 models driven by fusions or pathogenic mutations.
In my free time I like to knit warm socks and hats, crochet doilies, play video and role-playing games and tend to my collection of philodendrons and other aroids.