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Publications

Below is a list of our key publications. To see all publications affiliated to our group, click here.

* Equal contribution, # Corresponding author

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes.

Meister, M.T., Groot Koerkamp, M.J.A., de Souza, T., Breunis, W.B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H.H.D., Janse, A., Dolman, M.E.M., Eising, S., Langenberg, K.P.S., van Tuil, M., Knops, R.R.G., van Scheltinga, S.T., Hiemcke-Jiwa, L.S., Flucke, U., Merks, J.H.M., van Noesel, M.M., Tops, B.B.J., Hehir-Kwa, J.Y., Kemmeren, P., Molenaar, J.J., van de Wetering, M., van Boxtel, R., Drost, J.#, Holstege, F.C.P#.

EMBO Molecular Medicine 2022 Aug 2; e16001

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

Calandrini, C., Drost, J.#

STAR Protocols 2022; Jan 10;3(1):101079

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.

Calandrini, C., van Hooff, S.R., Paassen, I., Ayyildiz, D., Derakhshan, S., Dolman, M.E.M., Langenberg, K.P.S., van de Ven, M., de Heus, C., Liv, N., Kool, M., de Krijger, R.R., Tytgat, G.A.M., van den Heuvel-Eibrink, M.M., Molenaar, J.J., Drost, J.#

Cell Reports 2021 Aug 24; 36(8):109568.

Single cell derived mRNA signals across human kidney tumors.

Young, M.D.*, Mitchell, T.J.*, Custers, L.*, Margaritis, T., Morales-Rodriguez, F., Kwakwa, K., Khabirova, E., Kildisiute, G., Oliver, T.R.W., de Krijger, R.R., van den Heuvel-Eibrink, M.M., Comitani, F., Piapi, A., Bugallo-Blanco, E., Thevanesan, C., Burke, C., Prigmore, E., Ambridge, K., Roberts, K., Vieira Braga, F.A., Coorens, T.H.H., Del Valle, I., Wilbrey-Clark, A., Mamanova, L., Stewart, G.D., Gnanapragasam, V.J., Rampling, D., Sebire, N., Coleman, N., Hook, L., Warren, A., Haniffa, M., Kool, M., Pfister, S.M., Achermann, J.C., He, X., Barker, R.A., Shlien, A., Bayraktar, O.A, Teichmann, S., Holstege, F.C., Meyer, K.B., Drost, J.#, Straathof, K.#, Behjati, S.#

Nature Communications 2021 Jun 23; 12(1):3896.

Generation of Human Kidney Tubuloids from Tissue and Urine.

Calandrini, C., Drost, J.#.

Journal of Visualized Experiments 2021 Apr 16

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours.

Custers, L.*, Khabirova, E.*, Coorens, T.H.H.*, Oliver, T.R.W., Calandrini, C., Young, M.D., Vieira Braga, F.A., Ellis, P., Mamanova, L., Segers, H., Maat, A., Kool, M., Hoving, E.W., van den Heuvel-Eibrink, M.M., Nicholson, J., Straathof, K., Hook, L., de Krijger, R.R., Trayers, C., Allinson, K., Behjati, S.#, Drost, J.#. 

Nature Communications 2021 Mar 3; 12(1):1407.

In vitro Modeling of Embryonal Tumors.

Custers, L.*, Paassen, I.*, Drost, J.#.

Frontiers in Cell and Developmental Biology 2021 Feb 26

Organoid models of childhood kidney tumours.

Ooms, A.H.A.G.*, Calandrini, C.*, de Krijger, R.R., Drost, J.#.

Nature Reviews Urology 2020 Jun; 17(6):311-313.

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Calandrini, C.*, Schutgens, F.*, Oka, R., Margaritis, T., Candelli, T., Mathijsen, L., Ammerlaan, C., van Ineveld, R.L., Derakhshan, S., de Haan, S., Dolman, E., Lijnzaad, P., Custers, L., Begthel, H., Kerstens, H.H.D., Rookmaker, M., Verhaar, M., Tytgat, G.A.M., Kemmeren, P., de Krijger, R.R., Al-Saadi, R., Pritchard-Jones, K., Kool, M., Rios, A., van den Heuvel-Eibrink, M.M., Molenaar, J., van Boxtel, R., Holstege, F.C.P., Clevers, H., Drost, J.#.

Nature Communications 2020;11(1):1310.

Xenograft and organoid model systems in cancer research.

Bleijs, M., van de Wetering, M., Clevers, H., Drost, J.#.

EMBO Journal 2019;38(15):e101654.

Organoids in cancer research.

Drost, J.#, Clevers, H.

Nature Reviews Cancer 2018 Jul, 18(7): 407-418.

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression.

Fumagalli, A., Suijkerbuijk, S.J.E., Begthel, H., Beerling, E., Oost, K.C., Snippert, H.J., van Rheenen, J.#, Drost, J.#.

Nature Protocols 2018 Feb, 13 (2): 235 – 247.

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Drost, J.*, van Boxtel, R.*, Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J.E., van Wezel, T., Nik-Zainal, S., Kuiper, R.P., Cuppen, E., Clevers, H.

Science 2017 Oct 13, 358 (6360): 234 – 238.

Sequential cancer mutations in cultured human intestinal stem cells.

Drost, J., van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H.

Nature 2015 May 7, 521 (7550), 43 – 47.