I joined the Princess Máxima Center as a basic researcher and pediatrician in training in June 2018. My primary research interest lies in understanding the molecular biology of pediatric soft tissue sarcomas (STS) and to use that knowledge to develop new treatment options for patients suffering from these tumors. To this end, I study establishment procedures for novel preclinical models of pediatrist STS (i.e., tumor organoid models) as well as bulk and single-cell genomics of these tumors. I am furthermore member of the molecular tumor board of the Dutch iTHER as well as the German INFORM pediatric precision medicine trial.
My hobbies include sports (running, bootcamp) and gaming (board games, tabletop role-playing games, video games). I am the proud father of a boy and a girl.
Rugile Januškevičiūtė
PhD student
My project is focused on the tumour microenvironment of rhabdomyosarcoma (RMS), which is a soft tissue malignancy of mesenchymal origin. The cellular differentiation states underlying RMS, its immune microenvironment, and how these relate to patient outcomes remains unknown. I will be using single-cell omics approach to characterise the differentiation stages and immune landscape of RMS. Additionally, I will validate the potential therapeutic targets using patient-derived RMS organoid models and immune cell co-culture models.
Outside of work I try to immerse myself into sports - recently I got into running and completed my first half-marathon, therefore you will often find me in the evenings running around Utrecht. Additionally, I enjoy swimming and rowing - last year I even got to represent my university team in multiple races in London. Once tired from all the sports, I enjoy exploring new cities and reading books - even managed to start a bookclub over my time here!