I joined the Princess Máxima Center as a basic researcher and pediatrician in training in June 2018. My primary research interest lies in understanding the molecular biology of pediatric soft tissue sarcomas (STS) and to use that knowledge to develop new treatment options for patients suffering from these tumors. To this end, I study establishment procedures for novel preclinical models of pediatrist STS (i.e., tumor organoid models) as well as bulk and single-cell genomics of these tumors. I am furthermore member of the molecular tumor board of the Dutch iTHER as well as the German INFORM pediatric precision medicine trial.
My hobbies include sports (running, bootcamp) and gaming (board games, tabletop role-playing games, video games). I am the proud father of a boy and a girl.

Kostas Sofiadis
Post doc
My research at Prinses Máxima focuses on identifying the epigenetic determinants that drive tumor plasticity and dictate the progression of a subset of tumors caused by single mutations in key epigenetic factors. To this end, I apply advanced single-cell technologies to characterize the transcriptional and epigenetic landscape of patient-derived samples and established organoid lines, with the ultimate goal of reversing the malignant state.
Outside of science, I try to stay active playing football and padel and occasionally going to the gym. In my quieter moments, I’m working—often in vain—on improving my piano skills or enjoying time with friends over a beer or two.