I joined the Princess Máxima Center as a basic researcher and pediatrician in training in June 2018. My primary research interest lies in understanding the molecular biology of pediatric soft tissue sarcomas (STS) and to use that knowledge to develop new treatment options for patients suffering from these tumors. To this end, I study establishment procedures for novel preclinical models of pediatrist STS (i.e., tumor organoid models) as well as bulk and single-cell genomics of these tumors. I am furthermore member of the molecular tumor board of the Dutch iTHER as well as the German INFORM pediatric precision medicine trial.
My hobbies include sports (running, bootcamp) and gaming (board games, tabletop role-playing games, video games). I am the proud father of a boy and a girl.
Juliane Buhl
Post Doc
My passion for translational research in pediatric oncology brought me from the KiTZ in Heidelberg to the Prinses Máxima Centrum. As a pharmacist by training the translation of our research findings is my top priority. For patients with rhabdoid tumors there is an urgent need for novel, more efficient therapeutic options. We hypothesize that the block in differentiation during fetal development underpinning rhabdoid tumors could preserve unique embryonic antigens, which are no longer present in matured tissues. Such antigens could provide unique, tumor-specific markers that could potentially be used as therapeutic targets. I aim to develop immunotherapeutic strategies for rhabdoid tumors using cutting edge proteomics approaches in combination with unique patient-derived organoid and immune cell co-culture models.
Besides my passion for science, I enjoy singing and am part of the Maxima band and I participate in the “women in science” program in house to empower women as well as men during their scientific career.