I joined the Princess Máxima Center as a basic researcher and pediatrician in training in June 2018. My primary research interest lies in understanding the molecular biology of pediatric soft tissue sarcomas (STS) and to use that knowledge to develop new treatment options for patients suffering from these tumors. To this end, I study establishment procedures for novel preclinical models of pediatrist STS (i.e., tumor organoid models) as well as bulk and single-cell genomics of these tumors. I am furthermore member of the molecular tumor board of the Dutch iTHER as well as the German INFORM pediatric precision medicine trial.
My hobbies include sports (running, bootcamp) and gaming (board games, tabletop role-playing games, video games). I am the proud father of a boy and a girl.
Charlotte op 't Hoog
PhD student
I am Charlotte, PhD student in the Drost group since September 2022. My projects are mainly focused on the tumor microenvironment of malignant rhabdoid tumors of the brain. I study the interactions of the different rhabdoid subtypes with the immune system and surrounding tissue using proteomics approaches, patient-derived organoids and co-culture systems. We hope that by understanding the different interactions, we can identify novel subtype-specific therapeutic targets.
In my spare time, I love going into the city for drinks or dinner with my friends. I really enjoy electronic and rock music. Hence, you can often find me at festivals and concerts. Although just a beginner, I’m trying to become an electric guitar player myself. I also enjoy sports, such as climbing, running, yoga and winter sports.