I joined the Princess Máxima Center as a basic researcher and pediatrician in training in June 2018. My primary research interest lies in understanding the molecular biology of pediatric soft tissue sarcomas (STS) and to use that knowledge to develop new treatment options for patients suffering from these tumors. To this end, I study establishment procedures for novel preclinical models of pediatrist STS (i.e., tumor organoid models) as well as bulk and single-cell genomics of these tumors. I am furthermore member of the molecular tumor board of the Dutch iTHER as well as the German INFORM pediatric precision medicine trial.
My hobbies include sports (running, bootcamp) and gaming (board games, tabletop role-playing games, video games). I am the proud father of a boy and a girl.
Aleksandra Nenova
PhD student
In my PhD project, I investigate the differentiation trajectories in synovial sarcoma. Despite being genetically stable, this cancer is driven by an onco-fusion (SSX-SS18) which leads to an aberrant gene expression profile through disruption of the SWI/SNF chromatin remodeling complex. Using combined single cell RNA-seq and ATAC-seq and CRISPR editing on patient-derived organoid models, I aim to exploit epigenetic leads for the discovery of less toxic and more effective therapy.
Outside the lab, I enjoy board games, Dungeons & Dragons, knitting & crocheting, while my favourite way of staying active is pole sports.